Contrast-Enhanced Color Doppler Ultrasonography for Preoperative Evaluation of Sentinel Lymph Node in Breast Cancer Patients
Identifieur interne : 001F57 ( Main/Exploration ); précédent : 001F56; suivant : 001F58Contrast-Enhanced Color Doppler Ultrasonography for Preoperative Evaluation of Sentinel Lymph Node in Breast Cancer Patients
Auteurs : Dionysios Dellaportas [Grèce] ; Andreas Koureas [Grèce] ; John Contis [Grèce] ; Panagis M. Lykoudis [Grèce] ; Irene Vraka [Grèce] ; Dimitrios Psychogios [Grèce] ; Agatha Kondi-Pafiti [Grèce] ; Dionysios K. Voros [Grèce]Source :
- Breast Care [ 1661-3791 ] ; 2015.
Abstract
Sentinel lymph node (SLN) biopsy is the standard of care for breast cancer patients with non-palpable axillary lymph nodes. We evaluated the usefulness of contrast-enhanced ultrasonography in preoperative detection of malignant SLNs.
50 patients with breast cancer (median age: 60 years) underwent a color power Doppler ultrasonography with intravenous contrast (Sonovue®) preoperatively, and findings suggestive of metastatic disease to the SLN were documented. The final histopathological report and the radiological preoperative record were compared. Finally, the sensitivity, specificity and diagnostic accuracy of this evolving diagnostic modality were calculated.
Contrast-enhanced ultrasound scan identified a negative SLN in the axilla of 27 patients and final histopathology was negative for 30 cases in total, so negative predictive value was calculated as 90% and positive predictive value was 75%. Overall sensitivity was 83.33% and specificity was 84.38%. Moreover, the ability of contrast-enhanced ultrasound to differentiate between SLN status was only statistically significantly correlated with the actual final histopathological report (p < 0.001), while successful ultrasound prediction was not correlated with any factor.
SLN status can be evaluated preoperatively using contrast-enhanced color Doppler ultrasonography with high accuracy.
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DOI: 10.1159/000436958
PubMed: 26688681
PubMed Central: 4677709
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Lykoudis</name><affiliation wicri:level="3"><nlm:aff id="aff1">2nd Department of Surgery, University Hospital ‘Aretaieion’, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>2nd Department of Surgery, University Hospital ‘Aretaieion’, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Vraka, Irene" sort="Vraka, Irene" uniqKey="Vraka I" first="Irene" last="Vraka">Irene Vraka</name><affiliation wicri:level="3"><nlm:aff id="aff2">1st Department of Radiology, University Hospital ‘Aretaieion’, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>1st Department of Radiology, University Hospital ‘Aretaieion’, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Psychogios, Dimitrios" sort="Psychogios, Dimitrios" uniqKey="Psychogios D" first="Dimitrios" last="Psychogios">Dimitrios Psychogios</name><affiliation wicri:level="3"><nlm:aff id="aff1">2nd Department of Surgery, University Hospital ‘Aretaieion’, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>2nd Department of Surgery, University Hospital ‘Aretaieion’, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kondi Pafiti, Agatha" sort="Kondi Pafiti, Agatha" uniqKey="Kondi Pafiti A" first="Agatha" last="Kondi-Pafiti">Agatha Kondi-Pafiti</name><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Pathology, University Hospital ‘Aretaieion’, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Pathology, University Hospital ‘Aretaieion’, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Voros, Dionysios K" sort="Voros, Dionysios K" uniqKey="Voros D" first="Dionysios K." last="Voros">Dionysios K. Voros</name><affiliation wicri:level="3"><nlm:aff id="aff1">2nd Department of Surgery, University Hospital ‘Aretaieion’, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>2nd Department of Surgery, University Hospital ‘Aretaieion’, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author></analytic><series><title level="j">Breast Care</title><idno type="ISSN">1661-3791</idno><idno type="eISSN">1661-3805</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>Sentinel lymph node (SLN) biopsy is the standard of care for breast cancer patients with non-palpable axillary lymph nodes. We evaluated the usefulness of contrast-enhanced ultrasonography in preoperative detection of malignant SLNs.</p></sec><sec><title>Methods</title><p>50 patients with breast cancer (median age: 60 years) underwent a color power Doppler ultrasonography with intravenous contrast (Sonovue®) preoperatively, and findings suggestive of metastatic disease to the SLN were documented. The final histopathological report and the radiological preoperative record were compared. Finally, the sensitivity, specificity and diagnostic accuracy of this evolving diagnostic modality were calculated.</p></sec><sec><title>Results</title><p>Contrast-enhanced ultrasound scan identified a negative SLN in the axilla of 27 patients and final histopathology was negative for 30 cases in total, so negative predictive value was calculated as 90% and positive predictive value was 75%. Overall sensitivity was 83.33% and specificity was 84.38%. Moreover, the ability of contrast-enhanced ultrasound to differentiate between SLN status was only statistically significantly correlated with the actual final histopathological report (p < 0.001), while successful ultrasound prediction was not correlated with any factor.</p></sec><sec><title>Conclusions</title><p>SLN status can be evaluated preoperatively using contrast-enhanced color Doppler ultrasonography with high accuracy.</p></sec></div></front></TEI><affiliations><list><country><li>Grèce</li></country><region><li>Attique (région)</li></region><settlement><li>Athènes</li></settlement></list><tree><country name="Grèce"><region name="Attique (région)"><name sortKey="Dellaportas, Dionysios" sort="Dellaportas, Dionysios" uniqKey="Dellaportas D" first="Dionysios" last="Dellaportas">Dionysios Dellaportas</name></region><name sortKey="Contis, John" sort="Contis, John" uniqKey="Contis J" first="John" last="Contis">John Contis</name><name sortKey="Kondi Pafiti, Agatha" sort="Kondi Pafiti, Agatha" uniqKey="Kondi Pafiti A" first="Agatha" last="Kondi-Pafiti">Agatha Kondi-Pafiti</name><name sortKey="Koureas, Andreas" sort="Koureas, Andreas" uniqKey="Koureas A" first="Andreas" last="Koureas">Andreas Koureas</name><name sortKey="Lykoudis, Panagis M" sort="Lykoudis, Panagis M" uniqKey="Lykoudis P" first="Panagis M." last="Lykoudis">Panagis M. Lykoudis</name><name sortKey="Psychogios, Dimitrios" sort="Psychogios, Dimitrios" uniqKey="Psychogios D" first="Dimitrios" last="Psychogios">Dimitrios Psychogios</name><name sortKey="Voros, Dionysios K" sort="Voros, Dionysios K" uniqKey="Voros D" first="Dionysios K." last="Voros">Dionysios K. Voros</name><name sortKey="Vraka, Irene" sort="Vraka, Irene" uniqKey="Vraka I" first="Irene" last="Vraka">Irene Vraka</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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